Molecular biology of angiotensinogen.
نویسندگان
چکیده
منابع مشابه
Molecular biology of angiotensinogen.
A ngiotensinogen is a moderately abundant / \ 55,000-60,000 Da serum glycoprotein that is -Z \ the precursor to the angiotensin peptides and is the only known naturally occurring renin substrate. It is synthesized by a variety of cells, most prominently hepatocytes, adipocytes, and astrocytes. Most angiotensinogen is extracellular (it is constitutively secreted); thus, there is apparently no wa...
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Angiotensinogen gene expression is controlled in a tissue- and development-specific manner. Interestingly, the angiotensinogen gene is abundantly expressed in adipose tissues other than the liver, where it is mainly produced. We investigated the molecular mechanism of angiotensinogen gene expression in a 3T3-L1 preadipocyte-adipocyte system. Although angiotensinogen mRNA was barely detectable i...
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Systems biology and molecular biology can answer the same question in quite different ways, and frequently the answers given by one sub-discipline seem no answer at all to the other. For many molecular biologists, a systemslevel explanation leaves them feeling that, until the underlying molecular mechanisms are known, the approach is hopelessly superficial. For systems biologists, on the other ...
متن کاملCharacterization of different high molecular weight angiotensinogen forms.
BACKGROUND Angiotensinogen is the substrate for renin in the system that releases angiotensin II. This renin-angiotensin system is an important regulator of blood pressure (BP), and defects in the system are linked to the development of hypertension. Native angiotensinogen is a 62,000-dalton monomer, but various high molecular weight forms also exist, which have not been well characterized. Hig...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1991
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.17.3.263